2010 Fiscal Year Final Research Report
An assessment of the association between epigenetic alterations and epidemiological features
| Project/Area Number |
20790425
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
NOJIMA Masanori Sapporo Medical University (00457699)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 生活習慣 / 癌 / 分子疫学 / DNAメチル化 / エピジェネティクス / LINE-1 |
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| Research Abstract |
We conducted a cohort-based epigenetic study for assessment of the association of DNA methylation with lifestyle factors and cancer incidence, using stored serum donated from 206 healthy people in 1989. As the results, higher methylation levels of LINE-1 were observed in male samples (approx. 1%), but we found no significant association of methylation levels with lifestyle factors (other than exercise) and cancer incidence. This study suggests that the association of LINE-1 methylation levels in serum DNA with lifestyle factors and cancer incidence is limited, and the possibility of the use of long-term stored serum samples for assessment for DNA methylation.
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