Effects of oral exposure to pesticide residues in allergic diseases during early childhood.

2009 Fiscal Year Final Research Report

• Project/Area Number: 20790432
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Hygiene
• Research Institution: National Institute for Environmental Studies
• Principal Investigator: YANAGISAWA Rie National Institute for Environmental Studies, 環境健康研究領域, 研究員 (70391167)
• Project Period (FY): 2008 – 2009
• Keywords: 食品衛生

Research Abstract

Pesticide residues, ones of environmental pollutants, may increase the potency of allergens and thereby play a role in the onset and progression of allergic diseases. We determined whether oral exposure to pesticides in early childhood affect allergic diseases including atopic dermatitis and allergic airway inflammation in murine model. Exposure to pesticides did not show significant enhancing effects in atopic dermatitis-like skin lesions either male or female mice. On the other hand, γ- benzene hexachloride (BHC) aggravated allergen-related airway inflammation in female mice, but not male mice. Taken together, oral exposure to pesticides in early childhood can show various effects in the type of disorders and/or sex differences.