A novel diagnosis of acute cardiac death using Tenascin C (TN-C)

2009 Fiscal Year Final Research Report

• Project/Area Number: 20790462
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Legal medicine
• Research Institution: Kumamoto University
• Principal Investigator: OHTSU Yuki Kumamoto University, 大学院・生命科学研究部, 技術専門職員 (90404342)
• Project Period (FY): 2008 – 2009
• Keywords: テネイシンC(TN-C) / 急性心臓死 / 細胞傷害マーカー / 法医診断学

Research Abstract

Tenascin C (TN-C) was applied to postmortem serum samples and their levels were evaluated in 101 forensic autopsy cases within 48 postmortem hours. TN-C levels were 24.0-1,000< ng/ml in 101 forensic autopsy cases, most of which were quite higher than those of clinical levels. There were no relationship between the TN-C levels and autopsy data, such as cause of death, postmortem interval, agonal period time and serum CRP levels. Histopathology of cardiac tissues regarding their inflammation stages are now progressing.