2009 Fiscal Year Final Research Report
The therapeutic mechanisms of action of kakkonto in a mouse model of food allergy with gastrointestinal symptoms.
| Project/Area Number |
20790472
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | University of Toyama (2009)
Toyama Medical and Pharmaceutical University (2008) |
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Principal Investigator |
YAMAMOTO Takeshi University of Toyama, 和漢医薬学総合研究所, 助教 (70316181)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 食物アレルギー / 葛根湯 / 腸管粘膜免疫 / マイクロアレイ |
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| Research Abstract |
The number of patients with food allergy has increased dramatically over the last several decades. However, there is no effective drug for food allergies. My results indicate that kakkonto has therapeutic effects on the development of allergic diarrhea in mouse food allergy model. The development of allergic diarrhea resulted from the enhancement of immune responses and the infiltration of mucosal mast cells in the colon. Kakkonto has immunosuppressive effects on the enhanced immune responses and interferes with the infiltration of mucosal mast cells in the colons of food allergy mouse, leading to improvement of allergic symptoms. Moreover, the transcriptome analyses reveal that the effects of kakkonto is due to the regulation of the differentiation and the activation of T cells.
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