2009 Fiscal Year Final Research Report
Relationship between the adverse effect of kampo medicine and transporters
| Project/Area Number |
20790475
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Nagoya City University |
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Principal Investigator |
MAKINO Toshiaki Nagoya City University, 大学院・薬学研究科, 准教授 (80326561)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 東洋医学 / 甘草 / 偽アルドステロン症 / 有機アニオントランスポーター |
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| Research Abstract |
Glycyrrhizae Radix has the adverse effect to cause pseudoaldosteronism. It is considered that pseudoaldosteronism is induced by glycyrrhitinic acid (GA) that inhibits 11β-hydroxysteroid dehydrogenase II in renal tubular epithelial cells. The present study reveals that GA cannot pass through the membrane of epithelial cells, but 3-monoglucuronyl glycyrrhietinic acid (3MGA) can actively be transported through the membrane by orgaic anion transporters. It is suggested that the adverse effect of licorice would be occurred not by GA but 3MGA.
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