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2009 Fiscal Year Final Research Report

Searching for therapeutical agents of ALS from Natural resources.

Research Project

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Project/Area Number 20790478
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionNigata University of Phermacy and Applied Life Sciences

Principal Investigator

MICHIKO Sekiya  Nigata University of Phermacy and Applied Life Sciences, 薬学部, 助教 (40367412)

Project Period (FY) 2008 – 2009
Keywords東洋医学 / 筋萎縮性側索硬化症 / 漢方方剤 / 温脾湯 / 生薬
Research Abstract

We investigated the effect of a Chinese prescription, Wen-Pi-Tang, on the ALS model mouse SOD1G93A. Although the oral administration of Wen-Pi-Tang extract to SOD1G93A mice had no significant effect on body weight loss and survival time, Wen-Pi-Tang delayed disease onset. The administration of Wen-Pi-Tang was thought to delay disease onset by inhibiting glial cell activation.

  • Research Products

    (15 results)

All 2009 2008

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (7 results)

  • [Journal Article] Xanthones from Hypericum chinense and their cytotoxicity evaluation.2009

    • Author(s)
      Tanaka N, Kashiwada Y, Kim SY, Sekiya M, Ikeshiro Y, Takaishi Y.
    • Journal Title

      Phytochemistry 70(11-12)

      Pages: 1456-1461

    • Peer Reviewed
  • [Journal Article] Acylphloroglucinol, biyouyanagiol, biyouyanagin B, and related spiro-lactones from Hypericum chinense.2009

    • Author(s)
      Tanaka N, Kashiwada Y, Kim SY, Hashida W, Sekiya M, Ikeshiro Y, Takaishi Y.
    • Journal Title

      Journal of Natural Products 72(8)

      Pages: 1447-1452

    • Peer Reviewed
  • [Journal Article] The Chinese Prescription Wen-Pi-Tang Extract Delays Disease Onset in ALS Model Mice While Attenuating the Activation of Glial Cells in the Spinal Cord.2009

    • Author(s)
      Sekiya M, Ichiyanagi T, Ikeshiro Y, Yokozawa T.
    • Journal Title

      Biological & Pharmaceutical Bulletin 32(3)

      Pages: 382-388

    • Peer Reviewed
  • [Journal Article] Chromone and chromanone glucosides from Hypericum sikokumontanum and their anti-Helicobacter pylori activities.2009

    • Author(s)
      Tanaka N, Kashiwada Y, Nakano T, Shibata H, Higuchi T, Sekiya M, Ikeshiro Y, Takaishi Y.
    • Journal Title

      Phytochemistry 70(1)

      Pages: 141-146

    • Peer Reviewed
  • [Journal Article] Takaneones A-C, prenylated butylphloroglucinol derivatives from Hypericum sikokumontanum.2008

    • Author(s)
      Tanaka N, Kashiwada Y, Sekiya M, Ikeshiro Y, Takaishi Y.
    • Journal Title

      Tetrahedron Letters 49(17)

      Pages: 2799-2803

    • Peer Reviewed
  • [Journal Article] Tomoeones A-H, cytotoxic phloroglucinol derivatives from Hypericum ascyron.2008

    • Author(s)
      Hashida W, Tanaka N, Kashiwada Y, Sekiya M, Ikeshiro Y, Takaishi Y.
    • Journal Title

      Phytochemistry 69(11)

      Pages: 2225-2230

    • Peer Reviewed
  • [Journal Article] Active Compounds Isolated from Traditional Chinese Prescription Wen-Pi-Tang Protecting Against Peroxynitrite-Induced LLC-PK1 Cell Damage.2008

    • Author(s)
      Rhyu DY, Kang KS, Sekiya M, Tanaka T, Park JC, Yokozawa T.
    • Journal Title

      The American Journal of Chinese Medicine 36(4)

      Pages: 761-770

    • Peer Reviewed
  • [Journal Article] Effect on both aglycone and sugar moiety towards PhaseIImetabolism of anthocyanins.2008

    • Author(s)
      Ichiyanagi T, Shida Y, Rahman MM, Sekiya M, Hatano Y, Mtsumoto H, Hirayama M, Konishi T, Ikeshiro Y.
    • Journal Title

      Food Chemistry 110(2)

      Pages: 493-500

    • Peer Reviewed
  • [Presentation] 筋萎縮性側索硬化症モデルにおける温脾湯の抗酸化を介した作用2009

    • Author(s)
      関谷倫子, 横澤隆子
    • Organizer
      第30回グアニジノ化合物研究会
    • Place of Presentation
      筑波
    • Year and Date
      20090000
  • [Presentation] 筋萎縮性側索硬化症モデルマウスを用いた温脾湯の検討(2)2009

    • Author(s)
      関谷倫子, 一柳孝司, 池城安正, 東田千尋, 横澤隆子
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      20090000
  • [Presentation] 前駆脂肪細胞の分化調節機能を有する天然物(3) -かきのもとの分化促進作用成分について-2009

    • Author(s)
      鎌倉孝法, 三浦恵理, 柏田良樹, 関谷倫子, 一柳孝司, 池城安正, 高石喜久
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      20090000
  • [Presentation] 前駆脂肪細胞の分化調節機能を有する天然物(4) -青ジソ根部の分化抑制作用成分について-2009

    • Author(s)
      佐々木久子, 阿部有里子, 柏田良樹, 関谷倫子, 池城安正, 高石喜久
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      20090000
  • [Presentation] 筋萎縮性側索硬化症モデルマウスを用いた温脾湯の検討2008

    • Author(s)
      関谷倫子, 田原愛, 一柳孝司, 池城安正, 東田千尋, 横澤隆子
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      20080000
  • [Presentation] アントシアニンの構造と消化管吸収の関係2008

    • Author(s)
      一柳孝司, 関谷倫子, 田原愛, 波田野義比古, 池城安正
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      20080000
  • [Presentation] スイゼンジナ(Gynura bicolor DC. )に含まれる抗酸化成分の研究(その1)2008

    • Author(s)
      田原愛, 一柳孝司, 関谷倫子, 池城安正
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      20080000

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Published: 2011-06-18   Modified: 2016-04-21  

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