2009 Fiscal Year Final Research Report
A basic research in relation to stress and hypotension
| Project/Area Number |
20790480
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Kinki University |
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Principal Investigator |
FUNAKAMI Yoshinori Kinki University, 薬学部, 助教 (70449833)
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| Project Period (FY) |
2008 – 2009
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| Keywords | ストレス / 低血圧 / 起立性低血圧 / Head-up tilt試験 / 血管反応性 |
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| Research Abstract |
The SART (specific alternation of rhythm in temperature)-stressed rat, which is a model animal of autonomic imbalance, is associated with low blood pressure and tachycardia under both consciousness and anesthesia. Additionally, orthostatic hypotension (OH) is developed easily by postural manipulation of SART-stressed rats. Accordingly, we studied the influence of the adrenalin α1 receptor agonist phenylephrine on stress-induced OH. In SART-stressed rats, prolonged intravenous administration of phenylephrine reduced OH. Sympathetic dysfunction is suggested to be a factor underlying SART stress-induced OH.
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