2009 Fiscal Year Final Research Report
Analysis of the mechanism of fulminant hepatitis using a hepatitisB virus strain obtained from a patient in fulminant hepatitis outbreak
| Project/Area Number |
20790483
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
JUN Inoue Tohoku University, 病院, 医員 (60455821)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Keywords | 肝臓学 / ウイルス性肝炎 |
|---|
| Research Abstract |
To clarify the mechanism of fulminant hepatitis induced by hepatitis B virus (HBV), we focused on a HBV strain obtained from a patient in fulminant hepatitis outbreak, and investigated the significance of mutations found in the strain and the impact to the infected cells. As a result, we demonstrated that the HBV replicative intermediates of HBV with the mutations were increase in the cells, and HBV core protein was accumulated in the nucleus of HBV-transfected cells. Moreover, the strain had direct cytotoxicity, and a part mechanism of fulminant hepatitis was clarified.
|
