2009 Fiscal Year Final Research Report
Aiming for the improvement of regenerative ability of the liver from hepatic stem cells by analyzing the role of SDF-1
| Project/Area Number |
20790488
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Niigata University |
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Principal Investigator |
TSUCHIYA Ataunori Niigata University, 医歯学総合病院, 医員 (70464005)
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| Project Period (FY) |
2008 – 2009
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| Keywords | SDF-1 / 肝再生 |
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| Research Abstract |
In the liver, stromal cell derived factor-1 (SDF-1) is produced in the bile duct and hepatic stem/progenitor cells. In this study, we analyzed the role of SDF-1 by using the CXCR4 conditional knock out (KO) mice (CXCR4 is the receptor of SDF-1). By analyzing the liver damaged CXCR4 KO mice, we realized that although in the liver hepatic stem/progenitor cells increased, the recovery of liver regeneration was delayed. These results reveal that the role of SDF-1/CXCR4 axis works positive effect for liver regeneration.
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Research Products
(6 results)
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[Journal Article] Successful treatment of multiple lung metastases of hepatocellular carcinoma by combined chemotherapy with docetaxel, cisplatin and tegafur/uracil2009
Author(s)
Tsuchiya A, Imai M, Kamimura H, Togashi T, Watanabe K, Seki K, Ishikawa T, Ohta H, Yoshida T, Kamimura T
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Journal Title
World J Gastroenterol 15(14)
Pages: 1779-1781
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[Journal Article] Successful Treatment in a Case of Massive Hepatocellular Carcinoma with Paraneoplastic Syndrome2009
Author(s)
Tsuchiya A, Kubota T, Takizawa K, Yamada K, Wakai T, Matsuda Y, Honma T, Watanabe M, Shirai Y, Maruyama H, Nomoto M, Aoyagi Y
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Journal Title
Case reports in gastroenterology 3
Pages: 105-110
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