2009 Fiscal Year Final Research Report
Identification and character ization of novel transcription programs required for lipid synthesis in the liver
| Project/Area Number |
20790496
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
HARADA Nagakatsu The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 助教 (40359914)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 脂質合成 / 遺伝子 / 転写 / マウス / 脂肪肝 / mRNAバリアント / プロモーター |
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| Research Abstract |
Glycerol-3-phosphate acyltmnsferase (GPAT) acts as a rate limiting enzyme in de novo lipid synthesis. GPAT is now a candidate for targeted treatment of the excess lipid accumulation that is associated with obesity and Non-alcoholic Fatty Liver Disease. In the present study, I clarified mechanisms of enhanced GPAT gene expression induced by feeding or obesity using cultured cells and mice.
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