2010 Fiscal Year Final Research Report
The effect of DGAT on liver steatosis, fibrosis and carcinogenesis in murine NASH models.
| Project/Area Number |
20790503
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
YAMAGUCHI Kanji Kyoto Prefectural University of Medicine, 医学研究科, 助教(寄附講座) (50381950)
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| Research Collaborator |
ITOH Yoshito 京都府立医科大学, 医学研究科, 准教授 (70244613)
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| Project Period (FY) |
2008 – 2010
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| Keywords | DGAT / 炎症 / 肝脂肪化 / 肝線維化 |
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| Research Abstract |
Suppression of DGAT2, which is highly expressed in hepatocytes, ameliorated liver steatosis but worsened liver fibrosis. This observation suggests that triglyceride synthesis helps to protect the liver from lipotoxicity by buffering FFA accumulation.
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