2009 Fiscal Year Final Research Report
Effect of nitorosylated- and phosphorylated-RKIP on cell-proliferation signal in gastric cancer cells
| Project/Area Number |
20790505
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Josai University |
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Principal Investigator |
OHTAKE Kazuo Josai University, 薬学部, 助教 (50337482)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 癌 / 整理活性 / 蛋白質 / シグナル伝達 / 一酸化窒素 / ニトロソ化 / 細胞増殖 / 翻訳後修飾 |
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| Research Abstract |
The purpose of the current study is to evaluate the effect of nitorosylated- and phosphorylated-RKIP (Raf kinase inhibitor protein) on cell-proliferation signal in human gastric cancer (AGS) cells. RKIP-nitrosylation was significant reduction in the phophorylation level of RKIP in AGS cells. On the other hand, cell proliferation signal was up-regulated by an expressive increase in nitrosylation level of RKIP.
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