2009 Fiscal Year Final Research Report
The role of endoplasmic reticulum stress and mitochondria-dependent pathway in carcinogenesis of steatohepatitis.
| Project/Area Number |
20790508
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Juntendo University |
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Principal Investigator |
KON Kazuyoshi Juntendo University, 医学部, 助教 (30398672)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 肝臓病学 |
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| Research Abstract |
In vitro experiments using isolated mouse hepatocytes demonstrated that trans-fatty acid but not cis-fatty acid exacerbates hepatocyte death via increasing mitochondrial oxidative stress, although both cis-fatty acid and trans-fatty acid induces fatty accumulation in hepatocytes. In vivo experiments using obese mice indicated that trans-fatty acid containing diet increases endoplasmic reticulum stress and oxidative stress, followed by hepatocytes ballooning and death whereas cis-fatty acid containing diet induces simple liver steatosis. In conclusion, our findings suggested that trans-fatty acid diet is a potent risk factor of steatohepatitis.
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