2009 Fiscal Year Final Research Report
Induction of mobilization and differentiation of bone marrow stem cells for the treatment of fibrosis and liver regeneration
| Project/Area Number |
20790511
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Tokai University |
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Principal Investigator |
HIGASHIYAMA Reiichi Tokai University, 医学部, 奨励研究員 (80459495)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 肝線維症 / 骨髄細胞 / コラーゲン / マトリックス分解酵素 |
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| Research Abstract |
Overexpression of matrix metalloproteinase (MMP)-13 enhanced the migration of bone marrow (BM)-derived cells and their differentiation into sinusoidal cells in fibrotic liver. Expression of MMP-13/-9 mRNA and enzymatic activity of MMPs was detected in the regression of liver fibrosis in the model mice that produce MMP-13/-9 only by BM-derived cells. These results may suggest the therapeutic implications of MMPs in the repair and regeneration of fibrotic liver.
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[Journal Article] Negligible contribution of bone marrow-derived cells to collagen production during hepatic fibrogenesis in mice.2009
Author(s)
Reiichi Higashiyama, Tadashi Moro, Sachie Nakao, Kenichiro Mikami, Hiroshi Fukumitsu, Yoshitaka Ueda, Kazuo Ikeda, Eijiro Adachi, George Bou-Gharios, Isao Okazaki, Yutaka Inagaki
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Journal Title
Gastroenterology 137
Pages: 1459-1466
Peer Reviewed
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[Journal Article] Hepatocyte growth factor suppresses profibrogenic signal transduction via nuclear export of Smad3 with galectin-7.2008
Author(s)
Yutaka Inagaki, Kiyoshi Higashi, Miwa Kushida, Yun Yu Hong, Sachie Nakao, Reiichi Higashiyama, Tadashi Moro, Johbu Itoh, Toshiyuki Mikami, Toru Kimura, Goshi Shiota, Ichiro Kuwabara, Isao Okazaki
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Journal Title
Gastroenterology 134
Pages: 1180-1190
Peer Reviewed
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