2009 Fiscal Year Final Research Report
The analysis of relationships of lymphocyte differentiation, gastric mucosal immune response, and carcinogenic mechanism to signaling cascade of TGF-β.
| Project/Area Number |
20790516
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
FUKUI Toshiro Kansai Medical University, 医学部, 助教 (60402905)
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| Research Collaborator |
MIYOSHI Hideaki 関西医科大学, 医学部, 大学院生
FUKATA Norimasa 関西医科大学, 医学部, 大学院生
KOYABU Masaki 関西医科大学, 医学部, 大学院生
OKAZAKI Kazuichi 関西医科大学, 医学部, 教授 (70145126)
MATSUZAKI Koichi 関西医科大学, 医学部, 准教授 (70278638)
UCHIDA Kazushige 関西医科大学, 医学部, 講師 (40411516)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 癌 / 細菌 / シグナル伝達 / 発生・分化 / 免疫学 |
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| Research Abstract |
We studied the pathway of differentiation from Tn to Th17 or Treg from a standpoint of the different potion of phosphorylation of Smad2/3. However, we could not verify the hypothesis that the different portion of phosphorylation of Smad2/3 was branch point of differentiation. Additionally, the intensive expression of linker-phosphorylated Smad2/3 was observed not in the interstitium, such as immune cells, but in the specific region of the gastrointestinal epithelial cells, which would be relevant to the mucosal proliferation. In future, we will analyze these cells in detail and develop this study results.
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