2009 Fiscal Year Final Research Report
The effect of chemical chaperone on myocardial ischemia-reperfusion injury and infarction in mice
| Project/Area Number |
20790521
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
OKAJIMA Masaki Kanazawa University, 附属病院, 助教 (00361999)
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| Project Period (FY) |
2008 – 2009
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| Keywords | ERストレス / 虚血再灌流 / 心筋梗塞 / シャペロン |
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| Research Abstract |
We assessed the hypothesis that 4-PBA (chemical chaperone) reduces endoplasmic reticulum stress (ER stress) mediated apoptosis and protects against myocardial ischemia-reperfusion injury or myocardial infarction in mice. In result, 4-PBA reduced ER stress mediated apoptosis, decreased infarct size, maintained cardiac function and improved survival ratio in mice with ischemia-reperfusion. On the other hand, 4-PBA inhibited fibrosis and induced cardiac rupture in mice with myocardial infarction.
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[Journal Article]2010
Author(s)
Ootsuji, H., Honda, M., Kaneko, S., Usui S., Okajima., M, Okada, H., Sakai, Y., Takamura, T., Horimoto, K., Takamura, M.
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Journal Title
Circ Cardiovasc Genet 3(1)
Pages: 68-77
Peer Reviewed
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