2009 Fiscal Year Final Research Report
Elucidation of roles of TRPC ion channels in pathological cardiac remodeling
| Project/Area Number |
20790526
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
KINOSHITA Hideyuki Kyoto University, 大学院・医学研究科, 助教 (30467477)
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| Project Period (FY) |
2008 – 2009
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| Keywords | イオンチャネル / 心不全 / 心筋リモデリング |
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| Research Abstract |
In this study, to elucidate the possibility of TRPC ion channels as new therapeutic targets in the treatment of cardiac diseases, we applied TRPC inhibitors to several mice model of cardiac hypertrophy or heart failure. We found that TRPC inhibitors ameliorate the pathological cardiac hypertrophy in mice with cardiac hypertrophy. We also found that the cardioprotective hormone, atrial natriuretic peptide inhibits TRPC3/6 channel activities. Our study revealed the potential significance of TRPCs as novel therapeutic targets in the treatment of pathological cardiac remodeling.
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