2009 Fiscal Year Final Research Report
Role of renin-angiotensin system on atherosclerotic plaque rupture
| Project/Area Number |
20790532
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Ehime University |
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Principal Investigator |
SUZUKI Jun Ehime University, 大学院・医学系研究科, 講師 (40452693)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 分子血管病態学 |
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| Research Abstract |
The incidence of plaque rupture was significantly reduced in Apolipoprotein E (ApoE)/Angiotensin II type 1a receptor (AT_<1a>R) double knockout mice compared with ApoE knockout mice. Lipid accumulation, macrophage infiltration into the plaque, superoxide anion production, and matrix metalloproteinase activity were markedly attenuated in ApoE/AT_<1a>R knockout mice compared with ApoE knockout mice. These findings suggest that AT_<1a>R blocking could decrease the incidence of atherosclerotic plaque rupture, and that AT_<1a>R mediated inflammation, oxidative stress, and MMP activation may have an important role in plaque vulnerability.
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