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2010 Fiscal Year Final Research Report

Investigation into modifying factors in patients with hypertrophic cardiomyopathy caused by an identical disease-causing mutation

Research Project

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Project/Area Number 20790533
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionKochi University

Principal Investigator

KUBO Toru  Kochi University, 教育研究部医療学系, 助教 (80325422)

Project Period (FY) 2008 – 2010
Keywords臨床心血管病態学
Research Abstract

I investigated the genotype-phenotype correlations in hypertrophic cardiomyopathy (HCM). In genetic analysis, I reported some mutations associated with HCM, particularly mutations in cardiac myosin-binding protein C gene. In the studies of clinical phenotype in HCM, I focused on the left ventricular remodeling of this disease and reported several results including the usefulness of biomarkers for predicting the prognosis.

  • Research Products

    (28 results)

All 2011 2010 2009 2008 Other

All Journal Article (15 results) (of which Peer Reviewed: 15 results) Presentation (9 results) Book (4 results)

  • [Journal Article] Combined measurements of cardiac troponin I and brain natriuretic peptide are useful for predicting adverse outcome in hypertrophic cardiomyopathy.2011

    • Author(s)
      Kubo T, Kitaoka H, Matsumura Y, 他9名
    • Journal Title

      Circ J 75

      Pages: 919-926

    • Peer Reviewed
  • [Journal Article] Gender-specific differences in the clinical features of hypertrophic cardiomyopathy in a community-based Japanese population: results from Kochi RYOMA study.2010

    • Author(s)
      Kubo T, Kitaoka H, Okawa M, 他6名
    • Journal Title

      J Cardiol 56

      Pages: 314-319

    • Peer Reviewed
  • [Journal Article] Hypertrophic cardiomyopathy in the elderly.2010

    • Author(s)
      Kubo T, Kitaoka H, Okawa M, Nishinaga M, Doi YL
    • Journal Title

      Geriatr Gerontol Int 10

      Pages: 9-16

    • Peer Reviewed
  • [Journal Article] Serum cardiac troponin I is related to increased left ventricular wall thickness, left ventricular dysfunction, and male gender in hypertrophy cardiomyopathy2010

    • Author(s)
      Kubo T, Kitaoka H, Okawa M, 他9名
    • Journal Title

      Clin Cardiol 3

      Pages: 1-7

    • Peer Reviewed
  • [Journal Article] Hemolytic anemia in a patient with hypertrophic obstructive cardiomyopathy.2010

    • Author(s)
      Kubo T, Kitaoka H, Terauchi Y, 他5名
    • Journal Title

      J Cardiol 55

      Pages: 125-129

    • Peer Reviewed
  • [Journal Article] Plasma adiponectin levels and left ventricular remodeling in hypertrophic cardiomyopathy2010

    • Author(s)
      Kitaoka H, Kubo T, Okawa M, 他4名
    • Journal Title

      Int Heart J 51

      Pages: 51-55

    • Peer Reviewed
  • [Journal Article] Clinical features of the dilated phase of hypertrophic cardiomyopathy in comparison with those of dilated cardiomyopathy.2010

    • Author(s)
      Hamada T, Kubo T, Kitaoka H, 他10名
    • Journal Title

      Clin Cardiol 33

      Pages: 24-28

    • Peer Reviewed
  • [Journal Article] A frameshift deletion mutation in the cardiac myosin-binding protein C gene associated with dilated phase of hypertrophic cardiomyopathy and dilated cardiomyopathy.2010

    • Author(s)
      Hitomi N, Kubo T, Kitaoka H, 他7名
    • Journal Title

      J Cardiol 56

      Pages: 189-196

    • Peer Reviewed
  • [Journal Article] A novel cardiac myosin-binding prote in C S297X mutation in hypertrophic cardiomyopathy.2010

    • Author(s)
      Hirota T, Kubo T, Kitaoka H, 他8名
    • Journal Title

      J Cardiol 56

      Pages: 59-65

    • Peer Reviewed
  • [Journal Article] Clinical impact of atrial fibrillation in patients with hypertrophic cardiomyopathy.Results from Kochi RYOMA Study2009

    • Author(s)
      Kubo T, Kitaoka H, Okawa M, 他7名
    • Journal Title

      Circ J 73

      Pages: 1599-1600

    • Peer Reviewed
  • [Journal Article] Clinical profiles of hypertrophic cardiomyopathy with apical phenotype .comparison of pure-apical form and distal-dominant form.2009

    • Author(s)
      Kubo T, Kitaoka H, Okawa M, 他9名
    • Journal Title

      Circ J 73

      Pages: 2330-2336

    • Peer Reviewed
  • [Journal Article] Cardiac ankyrin repeat protein gene (ANKRD1) mutations in hypertrophy cardiomyopathy.2009

    • Author(s)
      Arimura T, Bos JM, Sato A, Kubo T, 他9名
    • Journal Title

      J Am Coll Cardiol 54

      Pages: 334-342

    • Peer Reviewed
  • [Journal Article] Utility of tissue Doppler imaging to predict exercise capacity in hypertrophic cardiomyopathy: comparison with B-type natriuretic peptide.2009

    • Author(s)
      Kitaoka H, Kubo T, Okawa M, 他5名
    • Journal Title

      J Cardiol 53

      Pages: 361-367

    • Peer Reviewed
  • [Journal Article] Hypertrophic cardiomyopathy with mild left ventricular remodeling: echocardiographic assessment using left ventricular wall motion score.2008

    • Author(s)
      Hayato K, Okawa M, Matsumura Y, Kitaoka H, Kubo T, 他7名
    • Journal Title

      J Cardiol 51

      Pages: 92-105

    • Peer Reviewed
  • [Journal Article] Impact of metalloproteinases on left ventricular remodeling and heart failure events in patients with hypertrophic cardiomyopathy.

    • Author(s)
      Kitaoka H, Kubo T, Okawa M, 他4名
    • Journal Title

      Circ J 74

      Pages: 1191-1196

    • Peer Reviewed
  • [Presentation] Combined measurements of cardiac troponin I and brain natriuretic peptide are useful for predicting adverse outcomes in hypertrophic cardiomyopathy2010

    • Author(s)
      Kubo T
    • Organizer
      ESC CONGRESS 2010
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2010-08-30
  • [Presentation] Combined measurements of cardiac troponin I and brain natriuretic peptide are useful for predicting adverse outcomes in hypertrophic cardiomyopathy2010

    • Author(s)
      Kubo T
    • Organizer
      第74回日本循環器学会総会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-22
  • [Presentation] Gender differences in the clinical features of hypertrophic cardiomyopathy in an unselected regional Japanese population: Results from Kochi RYOMA study2009

    • Author(s)
      久保亨
    • Organizer
      第13回日本心不全学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2009-10-30
  • [Presentation] 肥大型心筋症患者の病因遺伝子スクリーニング:重複遺伝子変異とその臨床的意義2009

    • Author(s)
      久保亨
    • Organizer
      第54回日本人類遺伝学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-24
  • [Presentation] 地域在住高齢心筋症患者の病態に関する検討2009

    • Author(s)
      久保亨
    • Organizer
      第51回日本老年医学会学術集会
    • Place of Presentation
      神奈川
    • Year and Date
      2009-06-20
  • [Presentation] Cardiac troponin I is related to increased left ventricular wall thickness, left ventricular dysfunction and male gender in hypertrophic Cardiomyopathy2009

    • Author(s)
      Kubo T
    • Organizer
      17th Asian Pacific Congress of Cardiology
    • Place of Presentation
      京都
    • Year and Date
      2009-05-20
  • [Presentation] Impact of atrial fibrillation in elderly patients with hypertrophic cardiomyopathy2009

    • Author(s)
      Kubo T
    • Organizer
      17th Asian Pacific Congress of Cardiology
    • Place of Presentation
      京都
    • Year and Date
      2009-05-20
  • [Presentation] Clinical profiles of hypertrophic cardiomyopathy with apical phenotype: comparison of pure-apical from and distal-dominant form2009

    • Author(s)
      久保亨
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-22
  • [Presentation] Genetic screening and compound mutations in patients with hypertrophic cardiomyopathy2009

    • Author(s)
      久保亨
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-22
  • [Book] 循環器疾患最新の治療2010-20112010

    • Author(s)
      久保亨、土居義典, 他
    • Total Pages
      186-190
    • Publisher
      南江堂
  • [Book] 循環器病学基礎と臨床2010

    • Author(s)
      久保亨、大川真理、北岡裕章、土居義典, 他
    • Total Pages
      976-993
    • Publisher
      西村書店
  • [Book] 新しい診断と治療のABC心筋症2008

    • Author(s)
      久保亨、北岡裕章、土居義典, 他
    • Total Pages
      280-282
    • Publisher
      最新医学社
  • [Book] 循環器科循環器疾患の発症・増悪関連遺伝子最近の話題2008

    • Author(s)
      久保亨、土居義典, 他
    • Total Pages
      543-547
    • Publisher
      科学評論社

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Published: 2012-02-13   Modified: 2016-04-21  

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