2009 Fiscal Year Final Research Report
Oxidative DNA damage and its defense mechanism in atherosclerosis
| Project/Area Number |
20790535
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
鳥巣 久美子 Kyushu University, 生体防御医学研究所, (非常勤研究員) (20448434)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 分子血管病態学 |
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| Research Abstract |
It is unknown that accumulation of oxidative DNA damage can accelerates atherosclerosis. We used Apoe^<-/-> mice overexpressing human MTH1 which catalyses 8-oxoGTP. The severity of atherosclerosis of hMTH1-Tg/Apoe^<-/-> mice was not different from Apoe-i- mice.
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