2009 Fiscal Year Final Research Report
The role of HMGB1 in the development and expansion of aortic aneurysm
Project/Area Number |
20790548
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Circulatory organs internal medicine
|
Research Institution | Keio University |
Principal Investigator |
KOHNO Takashi Keio University, 医学部, 共同研究員 (60327509)
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Project Period (FY) |
2008 – 2009
|
Keywords | 分子血管病態学 / 大動脈瘤 / 炎症性サイトカイン / 自然免疫 |
Research Abstract |
Experimental AAA model was induced by periaortic application of calcium chloride in male mice. The protein expression of HMGB1 was increased in the AAA, compared with those in control mice. We administered neutralizing anti-HMGB1 antibody (AAA/antiH) or control antibody (AAA/C) to AAA mice subcutaneously. HMGB1 blockade suppressed experimental AAA formation. The expression of proinflammatory cytokines, metalloproteinase-9 activity, and the number of macrophages in the aorta were reduced in AAA/antiH compared with AAA/C.
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[Presentation] 心筋梗塞後治癒過程と左室リモデリングにおけるhigh-mobility group box 1 proteinの役割2009
Author(s)
河野隆志, 安斉俊久, 内藤広太郎, 宮庄拓, 岡本実, 横田博, 山田晋吾, 前川裕一郎, 高橋寿由樹, 吉川勉, 石坂彰敏, 小川聡
Organizer
第19回日本循環薬理学会
Place of Presentation
京都
Year and Date
2009-11-21
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[Presentation] High mobility group box 1 protein expression is associated with expansion and rupture of human abdominal aortic aneurysm2009
Author(s)
Kohno T, Anzai T, Kaneko H, Shimizu H, Shimoda M, Miyasho T, Okamoto M, Yokota H, Yamada S, Yoshikawa T, Okada Y, Ishizaka A, Yozu R, Ogawa S.
Organizer
The 82nd annual session meeting of American Heart Association
Place of Presentation
Orlando, USA.
Year and Date
2009-11-15
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[Presentation] Serum high mobility group box 1 protein elevation is associated with acute respiratory distress syndrome following thoracic aortic aneurysm repair2009
Author(s)
Kohno T, Kohno T, Anzai T, Shimizu H, Kaneko H, Jo Y, Yamada S, Yoshikawa T, Ishizaka A, Yozu R, Ogawa S.
Organizer
European Society of Cardiology Congress 2009
Place of Presentation
Barcelona, Spain
Year and Date
2009-09-02
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[Presentation] ST上昇型心筋梗塞における血清HMGB1値上昇の臨床的意義2009
Author(s)
河野隆志, 安斉俊久, 安西淳, 金子英弘, 眞野恵範, 内藤広太郎, 前川裕一郎, 宮庄拓, 山田晋吾, 横田博, 吉川勉, 石坂彰敏, 小川聡
Organizer
第29回心筋梗塞研究会
Place of Presentation
東京
Year and Date
2009-07-11