2009 Fiscal Year Final Research Report
Lineage-specific survival signal of lung adenocarcinoma on the lung development master regulator
| Project/Area Number |
20790566
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
YAMAGUCHI Tomoya Nagoya University, 大学院・医学系研究科, 助教 (70452191)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 肺腺癌 / リネジ特異的マスター調節因子 / リネジ特異的生存シグナル |
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| Research Abstract |
Sustained TTF-1 expression plays a crucial role in the survival of lung adenocarcinoma, in addition to the development and maintenance of cell lineages in normal lung. In this study, we identified DOT-1, as a TTF-1-regulated gene, and we showed lung adenocarcinoma expressing DOT-1 are highly dependent on its expression for cell survival.
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