2009 Fiscal Year Final Research Report
Gal-9 expands immunosuppressive macrophages to ameliorate T-cell-mediated inflammation.
| Project/Area Number |
20790570
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kagawa University |
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Principal Investigator |
ARIKAWA Tomohiro Kagawa University, 医学部, 助教 (70452670)
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| Project Period (FY) |
2008 – 2009
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| Keywords | Galectin-9 / myeloid-derived suppressor cells / T-cell mediated inflammation |
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| Research Abstract |
Gal-9 expands the monocytic myeloid-derived suppressor cells (MDSCs) which can suppress T-cell functions in the lesion during experimental hypersensitivity pneumonitis. As well-known that MDSCs can be subdivided into Ly-6C or Ly-6G positive cells, Gal-9 induced Ly-6C positive monocytic MDSCs both in vivo and in vitro. We thus conclude that Gal-9 may be an inducer of monocytic MDSCs in the presence of bacterial component(s).
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[Journal Article] G alectin-9 expands immunosuppressive macrophages to ameliorate T cell-mediated lung inflammation.2010
Author(s)
C Arikawa T, Saita N, Oomizu S, Ueno M, Matsukawa A, Katoh S, Kojima K, Nagahara K, Miyake M, Yamauchi A, Kohrogi H, Hirashima M
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Journal Title
European Journal of Immunology 40(2)
Pages: 548-558
Peer Reviewed
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[Journal Article] G alectin-9 ameliorates immune complex-induced arthritis by regulating Fc gamma R expression on macrophages.2009
Author(s)
Arikawa T, Watanabe K, Seki M, Matsukawa A, Oomizu S, Sakata K, Sakata A, Ueno M, Saita N, Niki T, Hirashima M
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Journal Title
Clinical Immunology 133
Pages: 382-392
Peer Reviewed
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