2009 Fiscal Year Final Research Report
Investigation of the pathomechanisms of lung fibrosis by using bronchioalveolar epithelium-specific Pten deficient mice
| Project/Area Number |
20790573
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | University of Miyazaki |
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Principal Investigator |
YANAGI Shigehisa University of Miyazaki, 医学部, 助教 (60404422)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 肺線維症 / 分子標的治療 |
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| Research Abstract |
Idiopathic pulmonary fibrosis is a chronic, lethal interstitial lung disease resulting from abnormal wound healing that involves epithelial mesenchymal interaction and epithelial-mesenchymal transition (EMT). To clarify the biological role of PTEN, in bronchioalveolar epithelium in the pathogenesis of lung fibrosis in vivo. KO mice showed high mortality compared with the control after bleomycin administration due to hypoxia caused by aberrant lung fibrosis. Lungs of KO mice exhibited increased accumulation of myofibroblasts and type I collagen. EMT significantly increased in KO mice. These results suggested that bronchioalveolar PTEN expression plays a critical role in preventing lung fibrosis by regulating EMT.
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