Studies on host defense mechanisms of pulmonary collectins against Mycobacterium avium and Legionella pneumophila.

2009 Fiscal Year Final Research Report

• Project/Area Number: 20790574
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Respiratory organ internal medicine
• Research Institution: Sapporo Medical University
• Principal Investigator: ARIKI Shigeru Sapporo Medical University, 医学部, 助教 (80464478)
• Project Period (FY): 2008 – 2009
• Keywords: 呼吸器感染症 / 自然免疫 / 肺コレクチン / 細胞内寄生細菌

Research Abstract

Pulmonary collectins play important roles in innate immunity of the lung. In this study, we demonstrated that collectins prevent the spread of infection by inhibiting the growth of L. pneumophila and M. avium, and by agglutinating M. avium. Furthermore, collectins enhanced the clearance of L. pneumophila by macrophages.

Research Products

• [Journal Article] Pulmonary collectins protect macrophages against pore-forming activity of Legionella pneumophila and suppress its intracellular growth. (2010)
  • Author(s): Sawada K., Ariki S., Kojima T., Saito A., Yamazoe M., Nishitani C., Shimizu T., Takahashi M., Mitsuzawa H., Yokota S.I., Sawada N., Fujii N., Takahashi H., Kuroki Y.
  • Journal Title: J. Biol. Chem. Vol.285 Pages: 8434-8443
  • Peer Reviewed
• [Journal Article] 肺コレクチンによるレジオネラ菌の増殖抑制 (2009)
  • Author(s): 澤田格、有木茂、山添雅己、西谷千明、清水健之、高橋素子、横田伸一、藤井暢弘、高橋弘毅、黒木由夫
  • Journal Title: 分子呼吸器病 Vol.13 Pages: 117-119
• [Presentation] 非定型抗酸菌に対する肺コレクチンの生体防御機構 (2009)
  • Author(s): 有木茂、澤田格、藤井暢弘、賀佐伸省、西谷千明、清水健之、山添雅己、高橋素子、黒木由夫
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-24
• [Presentation] Roles of pulmonary collectins in host defense against Legionella pneumophila infection. (2009)
  • Author(s): Ariki S., Sawada K., Yamazoe M., Nishitani C., Shimizu T., Takahashi M., Yokota S., Fujii N., Takahashi H., Kuroki Y.
  • Organizer: Experimental Biology 2009
  • Place of Presentation: New Orleans、USA
  • Year and Date: 2009-04-19
• [Presentation] Pulmonary collectins interact with and aggregate Mycobacterium avium (2008)
  • Author(s): Ariki S., Sawada K., Gasa S., Fujii N., Yamazoe M., Shimizu T., Nishitani C., Takahashi M., Kuroki Y.
  • Organizer: The 8th Awaji International Forum on Infection and Immunity
  • Place of Presentation: 淡路
  • Year and Date: 2008-09-10