2009 Fiscal Year Final Research Report
The role of osteopontin in aldosterone-induced renal fibrosis
| Project/Area Number |
20790595
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | Ehime University |
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Principal Investigator |
IRITA Jun Ehime University, 医学部・附属病院, 医員 (00423442)
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| Project Period (FY) |
2008 – 2009
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| Keywords | オステオポンチン / アルドステロン / 腎線維化 / 酸化ストレス / 炎症 |
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| Research Abstract |
Osteopontin (OPN) has been implicated in the pathology of several renal conditions. The aim of the present study was to clarify the roles of OPN in aldosterone-mediated renal injury by infusing aldosterone into either wild type (WT) or OPN knockout mice (OPN^<-/->). We used uninephrectomized mice treated with aldosterone and high salt to exaggerate renal fibrosis. These results indicate OPN is a promoter of aldosterone-induced inflammation, oxidative stress and interstitial fibrosis in the kidney and suggest that inhibition of OPN may be a potential therapeutic target for prevention of renal injury.
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[Journal Article] Renal resistance index is a marker of future renal dysfunction in patients with essential hypertension.2010
Author(s)
Okura T, Kurata M, Irita J, Enomoto D, Jotoku M, Nagao T, Koresawa M, Kojima S, Hamano Y, Mashiba S, Miyoshi K, Higaki J.
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Journal Title
J Nephrol. 23
Pages: 175-80
Peer Reviewed
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