the phosphorous regulatory mechanism of OPG knockout mouse

2010 Fiscal Year Self-evaluation Report

• Project/Area Number: 20790601
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Kidney internal medicine
• Research Institution: Jikei University School of Medicine
• Principal Investigator: OHKIDO Ichiro Jikei University School of Medicine, 医学部, 助教 (40372966)
• Project Period (FY): 2008 – 2011
• Keywords: Osteoprotegerin / FGF-23

Research Abstract

生体内のリン代謝調節は、腎臓からの排泄・腸管からの吸収・骨との交換・細胞膜における輸送のバランスにより行われているが、血中リン濃度を規定している主たる因子は腎臓からのリン排泄で、ほとんど近位尿細管の管腔側のNaPi IIaによる再吸収によって決まっている。近年FGF-23と破骨細胞分化阻止因子(OCIF : Osteoclast inhibitory factor/OPG : Osteoprotegerin)が慢性腎不全における二次性副甲状腺機能亢進症の病態形成に重要な役割を演じていることが想定されている。しかしながら、FGF-23やOPGがPTHあるいは1α,25(OH)2D3調節系と如何なるネットワークを形成しているかは不明な点が多い。そこで我々は慢性腎不全モデルマウスにおけるOPG、FGF-23、klothoなどの分子学的役割を明らかにする。

Research Products

• [Journal Article] Difference in coronary artery intima and media calcification in autopsied patients with chronic kidney disease. (2011)
  • Author(s): Yoshida H, Yokoyama K, Yaginuma T, Ohkido I, Yamamoto H, Utsunomiya Y, Kawakami M, Hosoya T.
  • Journal Title: Clin Nephrol. 75(1) Pages: 1-7
• [Journal Article] L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism : an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (2010)
  • Author(s): Yokoyama K, Urashima M, Ohkido I, Kono T, Yoshida T, Muramatsu M, Niu T, Hosoya T.
  • Journal Title: Nephron Clin Pract. 115(4) Pages: c237-c243
• [Journal Article] The hypothesis that bone turnover influences FGF23 secretion. (2010)
  • Author(s): Ohkido I, Yokoyama K, Kagami S, Hosoya T.
  • Journal Title: Kidney Int. 77(8) Pages: 743
• [Journal Article] Persistent alpha-Klotho (a-Kl) expression in the parathyroid glands of patients with secondary hyperparathyroidism. (2010)
  • Author(s): Ohkido I, Yokoyama K, Imura A, Utsunomiya Y, Hosoya T, Nabeshima Y.
  • Journal Title: Nephrol Dial Transplant. 25(3) Pages: 1007-1008
• [Journal Article] Dihydropyridine- and voltage-sensitive Ca2+ entry in human parathyroid cells. (2009)
  • Author(s): Yokoyama K, Matsuba D, Adachi-Akahane S, Takeyama H, Tabei I, Suzuki A, Shibasaki T, Iida R, Ohkido I, Hosoya T, Suda N.
  • Journal Title: Exp Physiol. 94(7) Pages: 847-855
• [Journal Article] Osteoprotegerin affects the responsiveness of fibroblast growth factor-23 to high oral phosphate intake. (2008)
  • Author(s): Kagami S, Ohkido I, Yokoyama K, Shigematsu T, Hosoya T.
  • Journal Title: Clin Nephrol. 70(4) Pages: 306-311
• [Presentation] Vitamin D analogues with TGF- signal inhibition property ameliorates renal fibrotic lesions in UUO mice.
  • Author(s): Keitaro Yokoyama, Ichiro Ohkido, Ichiaki Ito, Akiko Murayama, Jun Yanagisawa, Tastuo Hosoya
  • Organizer: 2009 ASN 42th Annual Renal Week Meeting San diego