2011 Fiscal Year Final Research Report
the phosphorous regulatory mechanism of OPG knockout mouse
| Project/Area Number |
20790601
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
OHKIDO Ichiro 東京慈恵会医科大学, 医学部, 助教 (40372966)
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| Project Period (FY) |
2008 – 2011
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| Keywords | Osteoprotegerin / FGF-23 |
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| Research Abstract |
The phosphorus metabolic regulation is performed by the excretion from kidney, the absorption from intestinal tract, the exchange with bones, a balance of the transportation in the cell membrane. The main factor prescribing blood phosphorus concentrations is fixed by reabsorption by NaPi IIa of the lumen side of most proximal tubules by the phosphorus excretion from kidney. It is assumed that FGF-23 and OCIF : Osteoclast inhibitory factor/OPG : Osteoprotegerin) play the role that is important to clinical condition formation of the secondary hyperparathyroidism in the chronic renal failure. However, there are many any questions whether FGF-23 and OPG form PTH or 1α, 25(OH) 2D3 adjustment system and what kind of network. Therefore we determine molecular roles such as OPG in the chronic renal failure model mouse, FGF-23, klotho.
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[Journal Article] Dihydropyridine-and voltage-sensitive Ca2+entry in human parathyroid cells2009
Author(s)
Yokoyama K, Matsuba D, Adachi-Akahane S, Takeyama H, Tabei I, Suzuki A, Shibasaki T, Iida R, Ohkido I, Hosoya T, Suda N
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Journal Title
Exp Physiol
Volume: 94(7)
Pages: 847-55
Peer Reviewed
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