2009 Fiscal Year Final Research Report
A genetic screen for modifier of polyglutamine-induced neuronal dysfunction in vivo
| Project/Area Number |
20790612
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
FUJIKAKE Nobuhiro National Center of Neurology and Psychiatry, 神経研究所 疾病研究第四部, 科研費研究員 (60467595)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 遺伝学 / 遺伝子 / 神経科学 / 脳神経疾患 / ショウジョウバエ / 神経変性疾患 / ポリグルタミン病 / スクリーニング |
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| Research Abstract |
The neurological phenotypes of the polyglutamine (polyQ) diseases have been reported to be caused by neuronal dysfunction rather than cell death. However, the mechanisms involved in polyQ-induced neuronal dysfunction in vivo are not fully understood. To investigate the mechanisms of polyQ-induced neuronal dysfunction in vivo, we screened for modifier genes of neuronal dysfunction using a Drosophila polyQ disease model. As a result, we successfully identified Sup1 and Sup5 genes as new genes that are involved in the mechanisms of polyQ-induced neuronal dysfunction.
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[Journal Article] Residual laminin-binding activity and enhanced dystroglycan glycosylation by LARGE in novel model mice to dystroglycanopathy.2009
Author(s)
Kanagawa M, Nishimoto A, Chiyonobu T, Takeda S, Miyagoe-Suzuki Y, Wang F, Fujikake N, Taniguchi M, Lu Z, Tachikawa M, Nagai Y, Tashiro F, Miyazaki J, Tajima Y, Takeda S, Endo T, Kobayashi K, Campbell KP, Toda T.
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Journal Title
Hum. Mol. Genet. 18
Pages: 621-631
Peer Reviewed
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