2009 Fiscal Year Final Research Report
Therapeutic strategy for amyotrophic lateral sclerosis targeting D-serine, an exacerbating factor of glutamate excitotoxicity
| Project/Area Number |
20790623
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Keio University |
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Principal Investigator |
SASABE Jumpei Keio University, 医学部, 助教 (10398612)
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| Project Period (FY) |
2008 – 2009
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| Keywords | D-セリン / 筋萎縮性側索硬化症 |
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| Research Abstract |
In the present study, we investigated amyotrophic lateral sclerosis, one of motor neuron diseases, aiming at developing a novel therapeutic strategy. To suppress the increase of D-serine with disease progression, we searched for the D-serine modulating factor with the highest contribution. We reached a novel finding that the expression and activity of D-serine degrading enzyme, D-amino acid oxidase, was significantly reduced in spinal cord of a model mouse for amyotrophic lateral sclerosis. Increasing the DAO activity may benefit the progression of amyotrophic lateral sclerosis.
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