2009 Fiscal Year Final Research Report
Analysis of PINK1 stabilization molecular mechanism by Parkin
| Project/Area Number |
20790627
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Juntendo University |
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Principal Investigator |
KAHORI Shiba Juntendo University, 大学院・医学研究科, 博士研究員 (30468582)
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| Project Period (FY) |
2008 – 2009
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| Keywords | parkin / PINK1 |
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| Research Abstract |
In this study, we show that PINK1 recruits Parkin from the cytoplasm to mitochondria with low membrane potential to initiate the autophagic degradation of damaged mitochondria. Furthermore, we identified FK506-binding protein 38 : FKBP38 as a PINK1 binding protein with mitochondrial uncoupler Carbonyl cyanide m-chliirophenilhydrazone : CCCP treatment and FKBP38 stabilized PINK1 at the protein level.
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[Journal Article] PINK1 stabilized by mitochondrial depokarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy2010
Author(s)
Matsuda N, Sato S, Shiba K, Okatsu K, Saisho K, Gautier CA, Sou YS, Saiki S, Kawajiri S, Sato F, Kimura M, Komatsu M, Hattori N, Tanaka K.
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Journal Title
J Csll Biol 189(2)
Pages: 211-21
Peer Reviewed
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