Mechanism of pancreatic beta-cell regulation by signals from the liver

2009 Fiscal Year Final Research Report

• Project/Area Number: 20790635
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Metabolomics
• Research Institution: Tohoku University
• Principal Investigator: IMAI Junta Tohoku University, 病院, 助教 (80431500)
• Co-Investigator(Renkei-kenkyūsha): OKA Yoshitomo 東北大学, 大学院・医学系研究科, 教授 (70175256) ; KATAGIRI Hideki 東北大学, 大学院・医学系研究科, 教授 (00344664)
• Project Period (FY): 2008 – 2009
• Keywords: 糖尿病 / 臓器関連関 / インスリン分泌 / 膵β細胞増殖 / 再生治療 / 自律神経 / 肝臓

Research Abstract

The mechanism underlying compensatory beta-cell responses against insulin resistance is not well understood. We have identified that a neuronal relay, originating in the liver, is involved in compensatory beta-cell responses during obesity development. In addition, we have shown that modulation of this neuronal relay may serve as a potential strategy for beta-cell regenerative medicine. These results were published in Science, one of the most famous scientific journals in the world, and were transmitted all over the world via various media.

Research Products

• [Journal Article] Identification of a Novel Mechanism RegulatingβCell Mass: Neuronal relay from the Liver to PancreaticβCells. (2009)
  • Author(s): Imai J, Oka Y, Katagiri H
  • Journal Title: Islets 1 Pages: 73-75
• [Journal Article] Neural Relay from the Liver Induces Proliferation of PancreaticβCells: A Path to Regenerative Medicine using the Self-Renewal Capabilities. (2009)
  • Author(s): Katagiri H, Imai J, Oka y
  • Journal Title: Communicative & Integrative Biology 2 Pages: 425-427
• [Journal Article] Peginterferon (PEG-IFN) plus ribavirin combination therapy, but neither interferon nor PGE-IFN alone, induced type 1 diabetes in a patient with chronic hepatitis C. (2009)
  • Author(s): Ogihara T, Katagiri H, Yamada T, Kudo H, Imai J, Ishigaki Y, Hinokio Y, Yamagiwa Y, Ueno Y, Shimosegawa T, Oka Y
  • Journal Title: Intern Med 48 Pages: 1387-1390
  • Peer Reviewed
• [Journal Article] Eradication of insulin resistance. (2009)
  • Author(s): Imai J, Yamada T, Saito T, Ishigaki Y, Hinokio Y, Kotake H, Oka Y, Katagiri H
  • Journal Title: Lancet 374 Pages: 264
  • Peer Reviewed
• [Journal Article] Impact of plasma oxidized low-density lipoprotein removal on atherosclerosis. (2008)
  • Author(s): Ishigaki Y, Katagiri H, Gao J, Yamada T, Imai J, Uno K, Hasegawa Y, Kaneko K, Ogihara T, Ishihara H, Sato Y, Takikawa K, Nishimichi N, Matsuda H, Sawamura T, Oka Y
  • Journal Title: Circulation 118 Pages: 75-83
  • Peer Reviewed
• [Journal Article] Regulation of Pancreatic {beta} Cell Mass by Neuronal Signals from the Liver. (2008)
  • Author(s): Imai J, Katagiri H, Yamada T, Ishigaki Y, Suzuki T, Kudo H, Uno K, Hasegawa Y, Gao J, Kaneko K, Ishihara H, Niijima A, Nakazato M, Asano T, Minokoshi Y, Oka Y
  • Journal Title: Science 322 Pages: 1250-1254
  • Peer Reviewed
• [Presentation] 自律神経を介した肝臓-膵β細胞連関による膵β細胞増殖機構 (2009)
  • Author(s): 今井淳太
  • Organizer: 日本糖尿病学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-05-23
• [Presentation] 肝臓におけるERK経路活性化は膵島再生を促進する (2009)
  • Author(s): 今井淳太
  • Organizer: 日本糖尿病学会総会
  • Place of Presentation: 前橋
  • Year and Date: 2009-04-24
• [Presentation] 神経を介した臓器間連関による膵β細胞増殖機構 (2009)
  • Author(s): 今井淳太
  • Organizer: 日本糖尿病・肥満動物学会
  • Place of Presentation: 岡山
  • Year and Date: 2009-02-14
• [Patent(Industrial Property Rights)] 膵β細胞増殖促進剤、血中インスリン濃度上昇剤、血糖値低下剤、及び糖尿病治療・予防薬 (2008)
  • Inventor(s): 片桐秀樹、岡芳知、今井淳太
  • Industrial Property Rights Holder: 片桐秀樹、岡芳知、今井淳太
  • Industrial Property Number: 特願2007-114804
  • Filing Date: 2008-11-06