2009 Fiscal Year Final Research Report
Liganded-thyroid hormone receptor-α enhances proliferation of pancreatic β-cells
| Project/Area Number |
20790644
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | University of Yamanashi |
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Principal Investigator |
FURUYA Fumihiko University of Yamanashi, 医学部附属病院, 診療助教 (90456450)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 膵臓 / 糖尿病 / 再生医療 / 核内ホルモン受容体 / 甲状腺ホルモン |
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| Research Abstract |
Lineage tracing studies indicate that replication of existing beta-cells is important for beta-cell proliferation in adult animals. In rat pancreatic beta-cell lines (RIN5F), treatment with 100 nM of thyroid hormone (T3) enhances cell proliferation. This result suggests that T3 is required for beta-cell proliferation or replication.
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