2009 Fiscal Year Final Research Report
Role of Rho-associated kinase 2 in metabolic syndrome
Project/Area Number |
20790646
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Metabolomics
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Research Institution | Kyoto University |
Principal Investigator |
NOGUCHI Michio Kyoto University, 医学研究科, 特定研究員 (00432394)
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Project Period (FY) |
2008 – 2009
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Keywords | ROCK2 / メタボリックシンドローム / 脂肪細胞分化 |
Research Abstract |
We demonstrate that inhibition of ROCK2, not ROCK1, enhances adipogenesis accompanied by the upregulation of adipogenic transcription factors. Augmentation of insulin signaling may contribute to the enhancement of adipogenesis. Furtheremore, we focus on a cofactor as a novel mechanism associated with this pathway. ROCK2 heterozygous mice did not exhibit significant differences in metabolic parameters on standard chow and high fat diet compared with wild-type mice. Further studies will be needed.
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Research Products
(6 results)
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[Journal Article] Adipogenic differentiation of human induced pluripotent stem cells: comparison with that of human embryonic stem cells2009
Author(s)
D. Taura*, M. Noguchi*(* equally contributed), M. Sone, K. Hosoda, E. Mori, Y. Okada, K. Takahashi, K. Homma. N. Oyamada, M. Inuzuka, T. Sonoyama, K. Ebihara, N. Tamura, H. Itoh, H. Suemori, N. Nakatsuji, H. Okano, S. Yamanaka, K. Nakao
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Journal Title
FEBS Lett. 583(6)
Pages: 1029-1033
Peer Reviewed
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[Journal Article] Glucocorticoid reamplification within cells intensifies NF{kappa}B andMAPK signaling and reinforces inflammation in activated preadipocytes2009
Author(s)
T. Ishii-Yonemoto, H. Masuzaki, S. Yasue, S. Okada, C. Kozuka, T. Tanaka, M. Noguchi, T. Tomita, J. Fujikura, Y. Yamamoto, K. Ebihara, K. Hosoda, K. Nakao
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Journal Title
Am J Physiol Endocrinol Metab 298
Pages: 930-940
Peer Reviewed
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[Journal Article] Genetic and pharmacological inhibition of Rho-associated kinase II enhances adipogenesis.2007
Author(s)
M. Noguchi, K. Hosoda, J. Fujikura, M. Fujimoto, H. Iwakura, T. Tomita, T. Ishii, N. Arai, M. Hirata, K. Ebihara, H. Masuzaki, H. Itoh, S. Narumiya, K. Nakao.
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Journal Title
J Biol Chem. 282
Pages: 29574-29583
Peer Reviewed
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