2009 Fiscal Year Final Research Report
Role of the prolyl isomerase Pin1 in diabetes
| Project/Area Number |
20790648
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | Hiroshima University |
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Principal Investigator |
NAKATSU Yusuke Hiroshima University, 医歯薬学総合研究科, 助教 (20452584)
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| Project Period (FY) |
2008 – 2009
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| Keywords | Pin1 / IRS-1 / インスリンシグナル / KOマウス / ob / obマウス |
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| Research Abstract |
We identified prolyl isomerase Pin1 as IRS-1 binding protein. Pin1 overexpression enhanced insulin signaling, while pin1 knockdown suppressed. In addition, overexpression of Pin1 in ob/ob mouse liver elevated IRS-1 mediating insulin signaling, while Pin1 KO mouse exhibited insulin resistance and glucose intolerance. Taking all of these results together, we conclude that Pin1 plays an important role in the enhancement of IRS-1 mediating insulin actions.
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