2009 Fiscal Year Final Research Report
DDAH2 enhances insulin secretion in pancreatic islet by local NO production.
| Project/Area Number |
20790654
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | Keio University |
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Principal Investigator |
HASGAWA Kazuhiro Keio University, 医学部, 助教 (30424162)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 過剰発現マウス / 糖尿病 / インスリン |
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| Research Abstract |
Dimethylarginie dimethylaminohydrolase (DDAH) degrades asymmetric dimethylarginine (ADMA), an endogenous nitric oxide (NO) synthase inhibitor, and comprises 2 isoforms, DDAH1 and DDAH2. To investigate the in vivo role of DDAH2, we generated transgenic mice overexpressing DDAH2. The transgenic mice manifested reductions in plasma ADMA and elevations in NO levels. In addition, TG mice also showed that DDAH2 induced pancreatic insulin secretion through increasing local NO production and reducing ROS levels in diabetic condition.
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Research Products
(3 results)
