Investigation on the Significance of Natriuretic Peptide System in Peripheral Arterial Diseases and its Therapeutic Application

2009 Fiscal Year Final Research Report

• Project/Area Number: 20790660
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Endocrinology
• Research Institution: Kyoto University
• Principal Investigator: PARK Kwijun Kyoto University, 医学研究科, 非常勤講師 (20437221)
• Research Collaborator: TAMURA Naohsa 京都大学, 医学研究科, 講師 (40314207) ; SONOYAMA Takuhiro 京都大学, 医学研究科, 大学院生
• Project Period (FY): 2008 – 2009
• Keywords: ナトリウム利尿ペプチド / 末梢動脈疾患 / 受容体 / 遺伝子発現 / 治療法

Research Abstract

We tried to investigate the influence of diabetic status on the expression of natriuretic peptide receptors (NPRs) in the peripheral artery, but it was suggested that investigations using larger animals such as rats would be needed to address this issue. It was suggested that atrial natriuretic peptide (ANP) administration at a high dose in mice would result in the activation of sympathetic nervous system in response to the blood pressure decrease by ANP. In the skeletal muscle in mice with the high-fat diet-induced obesity and impaired glucose tolerance, mRNA expression of guanylyl cyclase (GC)-A, the signaling receptor for ANP and brain natriuretic peptide, was decreased and that of NPR-C, the clearance receptor for NPs, was increased as compared with mice fed normal chaw, indicating that obesity and impaired glucose tolerance would suppress the signaling of NP system.

Research Products

• [Journal Article] Inhibition of hepatic damage and liver fibrosis by brain natriuretic peptide. (2009)
  • Author(s): Takuhiro Sonoyama, Naohisa Tamura, Kazutoshi Miyashita, Kwijun Park, Naofumi Oyamada, Daisuke Taura, Megumi Inuzuka, Yasutomo Fukunaga, Masakatsu Sone, Kazuwa Nakao
  • Journal Title: FEBS Lett. 583 Pages: 2067-2070
  • Peer Reviewed
• [Journal Article] Therapeutic potential of atrial natriuretic peptide administration on peripheral arterial diseases. (2008)
  • Author(s): Kwijun Park, Hiroshi Itoh, Kenichi Yamahara, Masakatsu Sone, Kazutoshi Miyashita, Naofumi Oyamada, Naoya Sawada, Daisuke Taura, Megumi Inuzuka, Takuhiro Sonoyama, Hirokazu Tsujimoto, Yasutomo Fukunaga, Naohisa Tamura, Kazuwa Nakao
  • Journal Title: Endocrinology 149 Pages: 483-491
  • Peer Reviewed
• [Presentation] Therapeutic significance of atrial natriuretic peptide on peripheral arterial disease. (2010)
  • Author(s): Kwijun Park, Hiroshi Itoh, Kenichi Yamahara, Kazutoshi Miyashita, Naofumi Oyamada, Naoya Sawada, Daisuke Taura, Megumi Inuzuka, Takuhiro Sonoyama, Hirokazu Tsujimoto, Yasutomo Fukunaga, Naohisa Tamura, Kazuwa Nakao
  • Organizer: 14th International Congress of Endocrinology
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-03-27
• [Presentation] Therapeutic potential of brain natriuretic peptide for liver fibrosis. (2010)
  • Author(s): Takuhiro Sonoyama, Naohisa Tamura, Kazutoshi Miyashita, Kwijun Park, Naofumi Oyamada, Daisuke Taura, Megumi Inuzuka, Katsutoshi Kojima, Kyoko Honda, Yasutomo Fukunaga, Masakatsu Sone, Akihiro Yasoda, Hiroshi Arai, Kazuwa Nakao
  • Organizer: 14th International Congress of Endocrinology
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-03-27