2009 Fiscal Year Final Research Report
Oxidative stress induced change of Ubiquitin modification in Mineralocorticoid receptor and cardiovascular disorder
| Project/Area Number |
20790664
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Endocrinology
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
YOKOTA Kenichi The University of Tokyo, 分子細胞生物学研究所, 特任研究員 (50424156)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Keywords | MR / アルドステロン / ユビキチン / 転写 |
|---|
| Research Abstract |
Mineralocorticoid receptor(MR) is ubiquitinated and then led to proteasome mediated degradation by its ligand, Aldosterone.It is possible that oxidative stress may modify MR ubiquitination and thus change MR mediated transcription.The E3 ligase that regulates MR degradation is possibly UBR2 and it may modify MR degradation under oxidative stress.
|
