Functional analysis of AML1-target genes in hematological malignancy.

2009 Fiscal Year Final Research Report

• Project/Area Number: 20790670
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Hematology
• Research Institution: The University of Tokyo
• Principal Investigator: NAKAGAWA Masahiro The University of Tokyo, 医学部・附属病院, 助教 (10431850)
• Project Period (FY): 2008 – 2009
• Keywords: 血液内科学

Research Abstract

AML1-related leukemia exhibits distinctly activated NF-kB signaling. Inhibition of the NF-kB pathway in the leukemic cells with mutated AML1 efficiently blocks their growth.

Research Products

• [Presentation] AML1/Runx1 is a cytoplasmic attenuator of NF-kB signaling: implication in pathogenesis and targeted therapy of AML1-related leukemia. (2010)
  • Author(s): Nakagawa M, Shimabe M, Nishimoto N, Watanabe-Okochi N, Ichikawa M, Nannya Y, Imai Y, Kurokawa M.
  • Organizer: Keystone symposia "New Paradigms in Cancer Therapeutics"
  • Place of Presentation: Victoria, Canada
  • Year and Date: 2010-03-25
• [Presentation] AML1/Runx1 is a cytoplasmic attenuator of NF-kB signaling: implication in pathogenesis and targeted therapy of AML1-related leukemia. (2009)
  • Author(s): Nakagawa M, Shimabe M, Nishimoto N, Watanabe-Okochi N, Ichikawa M, Nannya Y, Imai Y, Kurokawa M
  • Organizer: The American Society of Hematology 51th Annual Meeting
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2009-12-05
• [Presentation] AML1/Runx1によるNF-κBシグナルの制御 (2009)
  • Author(s): 中川正宏, 今井陽一, 西本菜穂子, 市川幹, 黒川峰夫
  • Organizer: 第71回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-24
• [Presentation] AML1/Runx1によるNF-κBシグナルの制御 (2009)
  • Author(s): 中川正宏, 今井陽一, 西本菜穂子, 市川幹, 黒川峰夫
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] Critical regulation of NF-kB signaling by AML1/Runx1 in normal and malignant hematopoietic cells. (2009)
  • Author(s): Nakagawa M, Imai Y, Nishimoto N, Ichikawa M, Kurokawa M
  • Organizer: he 2009 International RUNX Meeting
  • Place of Presentation: Oxford, UK
  • Year and Date: 2009-08-19
• [Presentation] 白血病関連転写因子AML1/Runx1によるNF-κBシグナルの制御. (2009)
  • Author(s): 中川正宏, 今井陽一, 黒川峰夫
  • Organizer: 第13回日本がん分子標的治療学会学術集会
  • Place of Presentation: 徳島
  • Year and Date: 2009-06-25