2009 Fiscal Year Final Research Report
In vivo characterization of B cells with lymphoma-specific translocat in mice and their potential roles in lymphoma development.
| Project/Area Number |
20790673
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | Kyoto University |
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Principal Investigator |
NISHIKORI Momoko Kyoto University, 医学研究科, 助教 (60378635)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 染色体転座 / BCL2 |
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| Research Abstract |
To clarify how the BCL2/IGH translocation contributes to the development of lymphoma of germinal center B-cell origin, we used chimeric mouse models to examine the biological features of BCL2-overexpressing B cells. These cells showed a cell-autonomous differentiation preference for follicular B cells, and they have reduced responsiveness to terminal differentiation stimulation. We hypothesize that B cells that have undergone BCL2/IGH translocation might possibly be forced to localize in follicles, and accumulate genetic abnormalities by being subjected to recurrent stimulation.
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