2009 Fiscal Year Final Research Report
Analysis of induction mechanisms for tumor antigen-specific regulatory T cells in lymphoma
Project/Area Number |
20790681
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Hematology
|
Research Institution | Keio University |
Principal Investigator |
MATSUSHITA Maiko Keio University, 医学部, 助教 (10327520)
|
Project Period (FY) |
2008 – 2009
|
Keywords | 悪性リンパ腫 / 制御性T細胞 / がん抗原 |
Research Abstract |
To analyze the development mechanisms of regulatory T (Treg) cells in B cell lymphoma patients, we established a model system using 5C.C7 TCR-Tg/RAG^<-/-> mice and B cell lymphoma cells expressing antigen peptides with various TCR affinities and expression levels. We showed that intrathymically-injected agonistic antigen peptides could induce Treg cells in peripheral lymphoid tissues with high efficiency.
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Research Products
(1 results)