2009 Fiscal Year Final Research Report
Ligand screening and functional analysis of Tie1
| Project/Area Number |
20790685
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
MOMOSE Haruka National Institute of Infectious Diseases, 血液・安全性研究部, 主任研究官 (70415488)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 血液免疫学 / 造血幹細胞 |
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| Research Abstract |
Hematopoietic stem cells (HSCs) are clonogenic cells which possess self-renewal capacity and pluripotency for the maintenance and the repair of whole blood system. The regulation of HSCs is very important for blood homeostasis, however, the precise molecular mechanisms regulating HSCs remain elusive. In this work, I focused on Tie1, a receptor tyrosine kinase which is expressed in HSCs. I had searched ligands of this orphan receptor to understand the function of Tie1. Several candidates were identified.
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