2009 Fiscal Year Final Research Report
Identification of novel auto-antigen in IgG4-related disease by proteomic analysis and establishment of diagnostic methods
| Project/Area Number |
20790694
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
膠原病・アレルギー・感染症内科学
|
|---|
| Research Institution | Sapporo Medical University |
|---|
Principal Investigator |
YAMAMOTO Motohisa Sapporo Medical University, 医学部, 助教 (80404599)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Keywords | IgG4関連疾患 / ミクリッツ病 / プロテオミクス / 免疫沈降 / 自己抗原 |
|---|
| Research Abstract |
Mikulicz's disease is a representative disorder of systemic IgG4-related disease. Interestingly, hypocomplementemia is observed in a quarter of the patients with Mikulicz's disease, and circulating immune complexes are detected in a half of them. We extracted immune complexes from the serum of Mikulicz's disease patients by immuno-precipitation. The antigens, which consisted of the immune complexes, were gotten by acid dissociation. Proteomic analysis revealed a 13.1 kD protein. We expect that the detection of this protein in the serum leads to more accurate diagnosis of systemic IgG4-related disease.
|
