2010 Fiscal Year Final Research Report
Gene expression analysis of bone marrow CD34 positive cells in patients with rheumatoid arthritis
| Project/Area Number |
20790695
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Kitasato University |
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Principal Investigator |
HASHIMOTO Atsushi Kitasato University, 医学部, 助教 (50327376)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 関節リウマチ / 変形性関節症 / 骨髄 / FKBP5 |
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| Research Abstract |
The expression of mRNA for FKBP5 was significantly higher in rheumatoid arthritis (RA) BM CD34+ cells than those in osteoarthritis (OA). FKBP5 stable transfectant of RAW 264.7 (Mouse leukemic monocyte macrophage cell line) was made and stimulated with TNF-α, resulted in up-regulation of NFkB and transformation to fibroblast-like cells. This is a possible pathway linking bone marrow and arthritis in RA patients. Identification of the gene associated with pathogenesis of RA such as FKBP5 can lead to new fundamental gene therapy of RA.
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