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2009 Fiscal Year Final Research Report

Therapeutic effects of imatinib and selective PDGF receptor inhibitor in a mouse model of systemic sclerosis

Research Project

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Project/Area Number 20790696
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionShowa University

Principal Investigator

IYODA Masayuki  Showa University, 医学部・内科学講座腎臓内科学部門, 助教 (20384365)

Project Period (FY) 2008 – 2009
Keywords強皮症 / imatinib / B細胞
Research Abstract

We evaluated the therapeutic effects of imatinib on a mouse model of systemic sclerosis. Compared to controls, imatinib-treated tight skin (Tsk) mice had reduced dermal thickening(186.40±20.35 vs 101.96±16.64 μm, p <0.01). Furthermore, imatinib-treated mice had significantly reduced skin fibronectin, TGF-b and collagen type I mRNA expressions(collagen type I : -38% ; fibronectin:-46% ; TGF-β : -26%). In addition, imatinib treatment also significantly reduced the serum anti-Scl70 antibody levels compared to vehicle treatment(0.83±0.23 vs 0.38 ±0.05, p <0.05). Conclusion: Imatinib treatment showed therapeutic effects in Tsk mice. The results of this study suggest that imatinib may be a novel approach for treating systemic sclerosis.

  • Research Products

    (10 results)

All 2010 2009 Other

All Journal Article (2 results) Presentation (7 results) Book (1 results)

  • [Journal Article] Preventive and therapeutic effects of imatinib in Wistar-Kyoto rats with anti-glomerular basement membrane glomerulonephritis2010

    • Author(s)
      Iyoda M, et al
    • Journal Title

      Kidney Int 75

      Pages: 1060-1070

  • [Journal Article] Imatinib suppresses cryoglobulinemia and secondary membranoproliferative glomerulonephritis2009

    • Author(s)
      Iyoda M, et al
    • Journal Title

      J Am Soc Nephrol 20

      Pages: 68-77

  • [Presentation] ImatinibによるWKYラット抗GBM抗体腎炎の抑制効果

    • Author(s)
      伊與田雅之, 他
    • Organizer
      第52回日本腎臓学会学術総会
    • Place of Presentation
      横浜
  • [Presentation] Preventive and therapeutic effects of imatinib in Wistar-Kyoto rats with anti-glomerular basement membrane glomerulonephritis

    • Author(s)
      Iyoda M, et al
    • Organizer
      ERA-EDTA Congress 2009
    • Place of Presentation
      Milan
  • [Presentation] Nilotinib attenuates the progression of chronic renal failure in 5/6 nephrectomized rats Annual meeting

    • Author(s)
      Iyoda M, et al
    • Organizer
      American Society of Nephrology 2009
    • Place of Presentation
      San Diego
  • [Presentation] ImatinibによるWistar-Kyoto(WKY)ラット抗GBM抗体腎炎抑制効果

    • Author(s)
      伊與田雅之, 他
    • Organizer
      第10回腎炎・ネフローゼ研究会
    • Place of Presentation
      東京
  • [Presentation] CKDの発症・進展におよぼすチロシンキナーゼ阻害薬の治療効果

    • Author(s)
      伊與田雅之, 他
    • Organizer
      CKD Award 2009
    • Place of Presentation
      東京
  • [Presentation] 5/6腎摘ラットにおけるニロチニブの腎不全進行抑制効果

    • Author(s)
      伊與田雅之, 他
    • Organizer
      第10回腎不全病態治療研究会
    • Place of Presentation
      東京
  • [Presentation] Preventive and therapeutic effects of imatinib in anti-GBM glomerulonephritis induced in WKY rats

    • Author(s)
      Iyoda M, et al
    • Organizer
      Annual meeting, American Society of Nephrology 2008
    • Place of Presentation
      Philadelphia
  • [Book] Annual Review 2010腎炎の発症・進展におよぼすチロシンキナーゼ阻害薬の効果2010

    • Author(s)
      伊與田雅之, 他
    • Total Pages
      99-106
    • Publisher
      中外医学社

URL: 

Published: 2011-06-18   Modified: 2016-04-21  

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