Analysis of IL-33-induced allergic inflamma

2009 Fiscal Year Final Research Report

• Project/Area Number: 20790698
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Teikyo University
• Principal Investigator: SUZUKAWA Maho Teikyo University, 医学部, 助手 (20453699)
• Project Period (FY): 2008 – 2009
• Keywords: IL-33 / ST2 / 好塩基球 / 好酸球 / アレルギー学 / 喘息 / サイトカイン

Research Abstract

IL-33, recognized as one of the key cytokines enhancing Th2-balanced immune response exhibited a strong activating effect on human basophils and eosinophils. Although IL-33 did not show any effect on human bronchial epithelial cell line, it showed a significant worsening of eosinophilic inflammation in asthmatic mouse model when intranasally challenged with the antigen. Taken together, IL-33 may be a key cytokine in the pathogenesis of Th2-dominant allergic diseases, partly by acting on basophils and eosinophils.

Research Products

• [Journal Article] Human Basophils and Cytokines/Chemokines. (2009)
  • Author(s): Yamaguchi M, Koketsu R, Suzukawa M, Kawakami A, Iikura M
  • Journal Title: Allergol Int. 58(1) Pages: 1-10
  • Peer Reviewed
• [Journal Article] IL-33 induces human eosinophil activation. (2009)
  • Author(s): Maho Suzukawa, Masao Yamaguchi, Rikiya Koketsu, Motoyasu Iikura, Hiroyuki Nagase, Susumu Nakae, Kenji Matsumoto, Hirohisa Saito, Kouji Matsushima, Tetsuya Adachi, Ken Ohta, Kazuhiko Yamamoto
  • Journal Title: Int Arch Allergy Immunol 149(suppl1) Pages: 113
  • Peer Reviewed
• [Journal Article] Interleukin-33 enhances adhesion, CD11b expression and survival in human eosinophils. (2008)
  • Author(s): Suzukawa M, Koketsu R, Iikura M, Nakae S, Matsumoto K, Nagase H, Saito H, Matsushima K, Ohta K, Yamamoto K, Yamaguchi M
  • Journal Title: Lab Invest. 88(11) Pages: 1245-1253
  • Peer Reviewed
• [Journal Article] An IL-1 cytokine member, IL-33, induces human basophil activation via its ST2 receptor. (2008)
  • Author(s): Suzukawa M, Iikura M, Koketsu R, Nagase H, Tamura C, Komiya A, Nakae S, Matsushima K, Ohta K, Yamamoto K, Yamaguchi M
  • Journal Title: J Immunol. 181(9) Pages: 5981-5989
  • Peer Reviewed
• [Journal Article] IL-33-induced activation of human basophils and eosinophils via ST2.
  • Author(s): Maho Suzukawa, Masao Yamaguchi, Motoyasu Iikura, Rikiya Koketsu, Akiko Komiya, Hiroyuki Nagase, Susumu Nakae, Kenji Matsumoto, Hirohisa Saito, Kouji Matsushima, Kazuhiko Yamamoto, Ken Ohta
  • Journal Title: Inflammation and Regeneration (in press)
  • Peer Reviewed
• [Presentation] An IL-1 cytokine member, IL-33 induces human basophil and eosinophil activation via ST2.
  • Author(s): Maho Suzukawa, Motoyasu Iikura, Rikiya Koketsu, Akiko Komiya, Hiroyuki Nagase, Tetsuya Adachi, Susumu Nakae, Kenji Matsumoto, Hirohisa Saito, Kouji Matsushima, Kazuhiko Yamamoto, Masao Yamaguchi, Ken Ohta.
  • Organizer: 第38回免疫学会総会・学術集会にて発表.
  • Place of Presentation: 京都
• [Presentation] IL-33によるヒト好塩基球活性化.
  • Author(s): 鈴川真穂、飯倉元保、山口正雄、纐纈力也、小宮明子、中江進、長瀬洋之、足立哲也、松島綱治、山本一彦、大田健
  • Organizer: 第58回アレルギー学会秋期学術大会にて発表
  • Place of Presentation: 東京国際フォーラム
• [Presentation] IL-33によるヒト好酸球およびヒト好塩基球の活性化.
  • Author(s): 鈴川真穂、飯倉元保、纐纈力也、小宮明子、長瀬洋之、足立哲也、中江進、松本健治、斉藤博久、松島綱治、山本一彦、山口正雄、大田健
  • Organizer: 第21回気道病態研究会にて発表
  • Place of Presentation: 東京
• [Presentation] IL-33-induced activation of human basophils and eosinophils via ST2.
  • Author(s): Maho Suzukawa, Masao Yamaguchi, Motoyasu Iikura, Rikiya Koketsu, Akiko Komiya, Hiroyuki Nagase, Susumu Nakae, Kenji Matsumoto, Hirohisa Saito, Kouji Matsushima, Kazuhiko Yamamoto, Ken Ohta
  • Organizer: 第9回国際炎症学会(第30回日本炎症・再生医学会合同開催)にて発表
  • Place of Presentation: 京王プラザホテル
• [Presentation] IL-33によるアレルギー性気道炎症増悪機序の解析.
  • Author(s): 鈴川真穂, 原麻恵, 飯倉元保, 中江進, 長瀬洋之, 山口正雄, 大田健
  • Organizer: 第23回アレルギー・好酸球研究会2009にて発表
  • Place of Presentation: 大手町サンケイプラザ
• [Presentation] IL-33によるアレルギー性気道炎症増悪とその機序に関する解析.
  • Author(s): 鈴川真穂, 飯倉元保, 纐纈力也, 小宮明子, 長瀬洋之, 足立哲也, 中江進, 松本健治, 斉藤博久, 松島綱治, 山本一彦, 山口正雄, 大田健
  • Organizer: 第22回気道病態研究会にて発表
  • Place of Presentation: 東京
• [Presentation] IL-33によるアレルギー性気道炎症増悪機序の解析.
  • Author(s): 鈴川真穂, 原麻恵, 飯倉元保, 中江進, 長瀬洋之, 山口正雄, 大田健
  • Organizer: 第13回アレルギー・気道上皮細胞研究会にて発表
  • Place of Presentation: シェーンバッハ・サボー
• [Book] 炎症と免疫(【好塩基球 新たな視点からみたアレルギー性炎症の誘導】 IL-33によるヒト好塩基球活性化, 18(1)) (2010)
  • Author(s): 鈴川真穂
  • Total Pages: 28-34