2009 Fiscal Year Final Research Report
Dynamic in vivo imaging of osteoclast functions for development of novel therapeutics against bone-resorptive disorders
Project/Area Number |
20790708
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
膠原病・アレルギー・感染症内科学
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Research Institution | National Hospital Organization Osaka-Minami Medical Center |
Principal Investigator |
ISHII Masaru National Hospital Organization Osaka-Minami Medical Center, 免疫学フロンティア研究センター, 特任准教授 (10324758)
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Project Period (FY) |
2008 – 2009
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Keywords | 細胞・組織 / シグナル伝達 / 医療・福祉 / 薬理学 / トランスレーショナルリサーチ |
Research Abstract |
Osteoclasts are the only somatic cells with bone-resorbing capacity, and they play a critical role not only in normal bone homeostasis but also in the pathogenesis of bone destructive disorders such as rheumatoid arthritis and osteoporosis. To reveal the process of recruitment of osteoclast precursors to bone surface, I have exploited a new experimental method using intravital two-photon microscopy for bone tissues that have been originally developed. One of the specific subjects was the migration and positioning of osteoclast precursors by a combination of lipid mediator such as SIP and bone marrow chemokines. I believe this study provided a new concept in a variety of research field, and, beyond it basic implication, the findings led to insights into human diseases and the therapeutics.
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Research Products
(19 results)
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[Journal Article] Visualization and identification of IL-7 producing cells in reporter mice2009
Author(s)
Mazzucchelli R. Warming S, Lawrence SM, Ishii M, Abshari M, Feigenbaum L, Washington AV, Warner AC, Sims DJ, Li WQ, Hixon JA, Gray DUD, Rich BE, Morrow M, Anver MR, Cherry J, Naf D, Sternberg LR, McVicar DW, Farr AG, Germain RN, Rogers K, Copeland N, Durum SK
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Journal Title
PLoS One 4(11)
Pages: e7637
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