2009 Fiscal Year Final Research Report
A basic study finding a targeting point upon the Quorum Sensing System of pathogenic bacteria to develop new drug
| Project/Area Number |
20790709
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Infectious disease medicine
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
GOMI Kazunori Tohoku University, 病院, 助教 (20400335)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Keywords | Quorum sensing system / Homoserine lactone / パターン認識受容体 |
|---|
| Research Abstract |
Gram-negative bacteria produce homoserine lactones for genetic regulation of their own growth rate. In this study, the principal investigator shows the following facts ; (1) Mouse Macrophage-like cell line, RAW264.7, recognizes this molecule. (2) TLR2 and TLR4 that are pattern recognition receptors do not recognize this molecule. (3) By using a homoserine lactone attached biotin, the principal investigator shows that possibly there is a kind of receptor of this molecule on the cell membrane of RAW264.7 cell.
|
Research Products
(3 results)
