2009 Fiscal Year Final Research Report
A basic study finding a targeting point upon the Quorum Sensing System of pathogenic bacteria to develop new drug
| Project/Area Number |
20790709
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Infectious disease medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
GOMI Kazunori Tohoku University, 病院, 助教 (20400335)
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| Project Period (FY) |
2008 – 2009
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| Keywords | Quorum sensing system / Homoserine lactone / パターン認識受容体 |
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| Research Abstract |
Gram-negative bacteria produce homoserine lactones for genetic regulation of their own growth rate. In this study, the principal investigator shows the following facts ; (1) Mouse Macrophage-like cell line, RAW264.7, recognizes this molecule. (2) TLR2 and TLR4 that are pattern recognition receptors do not recognize this molecule. (3) By using a homoserine lactone attached biotin, the principal investigator shows that possibly there is a kind of receptor of this molecule on the cell membrane of RAW264.7 cell.
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