Development of new strategies for intractable infections associated with microbial biofilms.

2009 Fiscal Year Final Research Report

• Project/Area Number: 20790714
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Infectious disease medicine
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: KANEKO Yukihiro National Institute of Infectious Diseases, 生物活性物質部, 研究員 (90469958)
• Project Period (FY): 2008 – 2009
• Keywords: 難治性感染症 / バイオフィルム / 新規治療 / ガリウム / 鉄 / 緑膿菌 / 真菌 / ストレス応答

Research Abstract

In order to invent new strategies for intractable infections associated with microbial biofilms, basic and applicable investigation was performed.

Research Products

• [Journal Article] The effects of an hsp90 inhibitor on the paradoxical effect (2009)
  • Author(s): Kaneko Y, Ohno H, Imamura Y, Kohno S, Miyazaki Y.
  • Journal Title: Jpn J Infect Dis. 62(5) Pages: 392-3
• [Journal Article] Targeting a bacterial stress response to enhance antibiotic action (2009)
  • Author(s): Lee S, Hinz A, Bauerle E, Angermeyer A, Juhaszova K, Kaneko Y, Singh PK, Manoil C.
  • Journal Title: Proc Natl Acad Sci U S A. 106(34) Pages: 14570-5
• [Presentation] ストレス応答阻害によるCandida albicansの抗真菌薬耐性の制御真菌症フォーラム (2010)
  • Author(s): 金子幸弘、大野秀明、今村圭文、河野茂、宮崎義継
  • Organizer: 第11回学術集会
  • Place of Presentation: 東京
  • Year and Date: 20100300
• [Presentation] 緑膿菌のガリウム耐性機序とガリウム耐性の影響についての検討 (2010)
  • Author(s): 金子幸弘、大野秀明、宮崎義継、河野茂
  • Organizer: 第44回緑膿菌感染症研究会
  • Place of Presentation: 東京
  • Year and Date: 20100200
• [Presentation] Effects of antifungal combinations against Candidabiofilms and stress responses (2009)
  • Author(s): Kaneko Y, Ohno H, Imamura Y, Kohno S, Miyazaki Y.
  • Organizer: Interscience Conference of Antimicrobial Agents and Chemtherapy
  • Place of Presentation: 米国サンフランシスコ
  • Year and Date: 20090900
• [Presentation] Pradeep Singh難治性緑膿菌呼吸器感染症に対するガリウム治療の呼吸機能等に与える影響 (2009)
  • Author(s): 金子幸弘、大野秀明、宮暗義継
  • Organizer: 第49回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 20090600
• [Presentation] 難治性緑膿菌感染症に対するガリウム治療の効果および耐性機序に関する検討 (2009)
  • Author(s): 金子幸弘、大野秀明、宮暗義継、河野茂
  • Organizer: 第57回日本化学療法学会総会
  • Place of Presentation: 東京
  • Year and Date: 20090600
• [Presentation] Combination therapy of micafungin with voriconazole and amphotericin B against Candida biofilms (2009)
  • Author(s): Kaneko Y, Ohno H, Imamura Y, Kohno S, Miyazaki Y.
  • Organizer: International Society for Human and Animal Mycology
  • Place of Presentation: 東京
  • Year and Date: 20090500
• [Presentation] Hsp90 inhibitor preferentially attenuates postnadir resistance to micafungin and tolerance to voriconazole of Candida albicans (2009)
  • Author(s): Kaneko Y, Ohno H, Imamura Y, Kohno S, Miyazaki Y.
  • Organizer: International Society for Human and Animal Mycology
  • Place of Presentation: 東京
  • Year and Date: 20090500
• [Presentation] Hsp9O inhibitor preferentially attenuates postnadir resistance to micafungin and tolerance to voriconazole of Candida albicans (2009)
  • Author(s): Kaneko Y, Ohno H, Imamura Y, Kohno S, Miyazaki Y.
  • Organizer: General meeting of American Society for Microbiology
  • Place of Presentation: 米国フィラデルフィア
  • Year and Date: 20090500
• [Presentation] Voriconazole attenuates the effect of micafungin against Candidabiofilms in vitro possibly via stress responses (2009)
  • Author(s): Kaneko Y, Ohno H, Imamura Y, Kohno S, Miyazaki Y.
  • Organizer: General meeting of American Society for Microbiology
  • Place of Presentation: 米国フィラデルフィア
  • Year and Date: 20090500
• [Presentation] Candida albicansのbiofilmに対するmicafunginとvoriconazole (2009)
  • Author(s): 金子幸弘、大野秀明、今村圭文、河野茂、宮崎義継
  • Organizer: amphotericin Bとの併用効果第83回日本感染症学会総会・学術講演会
  • Place of Presentation: 東京
  • Year and Date: 20090400
• [Presentation] 緑膿菌バイオフィルムに対するガリウム(Ga)の作用についての検討 (2009)
  • Author(s): 金子幸弘
  • Organizer: 第43回緑膿菌感染症研究会
  • Place of Presentation: 京都
  • Year and Date: 20090200
• [Presentation] Candida albicansのbiofilmに対するミカファンギンとボリコナゾール、アムホテリシンBとの併用効果 (2008)
  • Author(s): 金子幸弘
  • Organizer: 第52回日本医真菌学会・第7回国際クリプトコックス会議
  • Place of Presentation: 長崎
  • Year and Date: 20080900
• [Presentation] 難治性緑膿菌呼吸器感染症に対するガリウム治療の試み (2008)
  • Author(s): 金子幸弘
  • Organizer: 第48回日本呼吸器学会
  • Place of Presentation: 神戸
  • Year and Date: 20080600
• [Remarks] 該当せず