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2009 Fiscal Year Final Research Report

Development of new strategies for intractable infections associated with microbial biofilms.

Research Project

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Project/Area Number 20790714
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Infectious disease medicine
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

KANEKO Yukihiro  National Institute of Infectious Diseases, 生物活性物質部, 研究員 (90469958)

Project Period (FY) 2008 – 2009
Keywords難治性感染症 / バイオフィルム / 新規治療 / ガリウム / 鉄 / 緑膿菌 / 真菌 / ストレス応答
Research Abstract

In order to invent new strategies for intractable infections associated with microbial biofilms, basic and applicable investigation was performed.

  • Research Products

    (16 results)

All 2010 2009 2008 Other

All Journal Article (2 results) Presentation (13 results) Remarks (1 results)

  • [Journal Article] The effects of an hsp90 inhibitor on the paradoxical effect2009

    • Author(s)
      Kaneko Y, Ohno H, Imamura Y, Kohno S, Miyazaki Y.
    • Journal Title

      Jpn J Infect Dis. 62(5)

      Pages: 392-3

  • [Journal Article] Targeting a bacterial stress response to enhance antibiotic action2009

    • Author(s)
      Lee S, Hinz A, Bauerle E, Angermeyer A, Juhaszova K, Kaneko Y, Singh PK, Manoil C.
    • Journal Title

      Proc Natl Acad Sci U S A. 106(34)

      Pages: 14570-5

  • [Presentation] ストレス応答阻害によるCandida albicansの抗真菌薬耐性の制御真菌症フォーラム2010

    • Author(s)
      金子幸弘、大野秀明、今村圭文、河野茂、宮崎義継
    • Organizer
      第11回学術集会
    • Place of Presentation
      東京
    • Year and Date
      20100300
  • [Presentation] 緑膿菌のガリウム耐性機序とガリウム耐性の影響についての検討2010

    • Author(s)
      金子幸弘、大野秀明、宮崎義継、河野茂
    • Organizer
      第44回緑膿菌感染症研究会
    • Place of Presentation
      東京
    • Year and Date
      20100200
  • [Presentation] Effects of antifungal combinations against Candidabiofilms and stress responses2009

    • Author(s)
      Kaneko Y, Ohno H, Imamura Y, Kohno S, Miyazaki Y.
    • Organizer
      Interscience Conference of Antimicrobial Agents and Chemtherapy
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      20090900
  • [Presentation] Pradeep Singh難治性緑膿菌呼吸器感染症に対するガリウム治療の呼吸機能等に与える影響2009

    • Author(s)
      金子幸弘、大野秀明、宮暗義継
    • Organizer
      第49回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      20090600
  • [Presentation] 難治性緑膿菌感染症に対するガリウム治療の効果および耐性機序に関する検討2009

    • Author(s)
      金子幸弘、大野秀明、宮暗義継、河野茂
    • Organizer
      第57回日本化学療法学会総会
    • Place of Presentation
      東京
    • Year and Date
      20090600
  • [Presentation] Combination therapy of micafungin with voriconazole and amphotericin B against Candida biofilms2009

    • Author(s)
      Kaneko Y, Ohno H, Imamura Y, Kohno S, Miyazaki Y.
    • Organizer
      International Society for Human and Animal Mycology
    • Place of Presentation
      東京
    • Year and Date
      20090500
  • [Presentation] Hsp90 inhibitor preferentially attenuates postnadir resistance to micafungin and tolerance to voriconazole of Candida albicans2009

    • Author(s)
      Kaneko Y, Ohno H, Imamura Y, Kohno S, Miyazaki Y.
    • Organizer
      International Society for Human and Animal Mycology
    • Place of Presentation
      東京
    • Year and Date
      20090500
  • [Presentation] Hsp9O inhibitor preferentially attenuates postnadir resistance to micafungin and tolerance to voriconazole of Candida albicans2009

    • Author(s)
      Kaneko Y, Ohno H, Imamura Y, Kohno S, Miyazaki Y.
    • Organizer
      General meeting of American Society for Microbiology
    • Place of Presentation
      米国フィラデルフィア
    • Year and Date
      20090500
  • [Presentation] Voriconazole attenuates the effect of micafungin against Candidabiofilms in vitro possibly via stress responses2009

    • Author(s)
      Kaneko Y, Ohno H, Imamura Y, Kohno S, Miyazaki Y.
    • Organizer
      General meeting of American Society for Microbiology
    • Place of Presentation
      米国フィラデルフィア
    • Year and Date
      20090500
  • [Presentation] Candida albicansのbiofilmに対するmicafunginとvoriconazole2009

    • Author(s)
      金子幸弘、大野秀明、今村圭文、河野茂、宮崎義継
    • Organizer
      amphotericin Bとの併用効果第83回日本感染症学会総会・学術講演会
    • Place of Presentation
      東京
    • Year and Date
      20090400
  • [Presentation] 緑膿菌バイオフィルムに対するガリウム(Ga)の作用についての検討2009

    • Author(s)
      金子幸弘
    • Organizer
      第43回緑膿菌感染症研究会
    • Place of Presentation
      京都
    • Year and Date
      20090200
  • [Presentation] Candida albicansのbiofilmに対するミカファンギンとボリコナゾール、アムホテリシンBとの併用効果2008

    • Author(s)
      金子幸弘
    • Organizer
      第52回日本医真菌学会・第7回国際クリプトコックス会議
    • Place of Presentation
      長崎
    • Year and Date
      20080900
  • [Presentation] 難治性緑膿菌呼吸器感染症に対するガリウム治療の試み2008

    • Author(s)
      金子幸弘
    • Organizer
      第48回日本呼吸器学会
    • Place of Presentation
      神戸
    • Year and Date
      20080600
  • [Remarks] 該当せず

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Published: 2011-06-18   Modified: 2016-04-21  

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