2010 Fiscal Year Final Research Report
Non-invasive evaluation of the pulmonary hypertension and inhibition of pulmonary vascular remodeling by bosentan.
| Project/Area Number |
20790716
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
SUGIMOTO Masaya Asahikawa Medical College, 医学部, 助教 (20400096)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 肺高血圧 / ボセンタン / リモデリング / シンチグラフィー |
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| Research Abstract |
We measured various kinds of blood biomarkers to evaluate the progression of pulmonary hypertension. Serum BNP and NT-proBNP which are known as heart failure marker were significantly increased in patients with pulmonary hypertension. PIIIP which is a marker of the myocardial collagen metabolism was increased by right ventricle pressure overload such as pulmonary hypertension. High sensitivity troponin I (cTnI) which is the most sensitive marker of the myocardial injury was significantly increased in patients with pulmonary hypertension. Furthermore, serum cTnI levels significantly correlated with pulmonary systemic blood pressure ratio (Pp/Ps).
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